Contagious bovine pleuropneumonia (CBPP) caused by Mycoplasma mycoides subsp.
mycoides (Mmm) is an economically very important cattle disease in sub-Saharan Africa.
CBPP impacts animal health and poverty of livestock-dependent people through decreased
animal productivity, reduced food supply, and the cost of control measures. CBPP is a barrier
to trade in many African countries and this reduces the value of livestock and the income of
many value chain stakeholders. The presence of CBPP also poses a constant threat to CBPPfree
countries and creates costs in terms of the measures necessary to ensure the exclusion of
disease. This opinion focuses on the biomedical research needed to foster the development of
better control measures for CBPP. We suggest that different vaccine development approaches
are followed in parallel. Basic immunology studies and systematic OMICs studies will be
necessary in order to identify the protective arms of immunity and to shed more light on the
pathogenicity mechanisms in CBPP. Moreover a robust challenge model and a close
collaboration with African research units will be crucial to foster and implement a new
vaccine for the progressive control of this cattle plague.
Jores, J., Mariner, J.C. and Naessens, J. 2013. Development of an improved vaccine for contagious bovine pleuropneumonia: An African perspective on challenges and proposed actions. BMC Veterinary Research 44:122